电子健康记录（EHR）可获得的丰富纵向个体水平数据可用于检查治疗效果异质性。但是，使用EHR数据估算治疗效果提出了几个挑战，包括时变的混杂，重复和时间不一致的协变量测量，治疗分配和结果以及由于辍学导致的损失。在这里，我们开发了纵向数据（SDLD）算法的亚组发现，该算法是一种基于树的算法，用于使用纵向相互作用树算法结合使用纵向相互作用的一般数据驱动的方法，与纵向驱动的方法与纵向驱动的方法结合使用纵向相互作用，以发现具有异质治疗效果的亚组，并进行纵向研究。目标最大似然估计。我们将算法应用于EHR数据，以发现患有人免疫缺陷病毒（HIV）的人群的亚组，他们在接受非Dolutegravir抗逆转录病毒疗法（ART）接受非Dolutegravir抗逆转录病毒疗法（艺术）时的体重增加风险较高。

多项式概率贝叶斯添加剂回归树（MPBART）框架是由Kindo等人提出的。 （KD），与BART的多项式概率（MNP）模型中的潜在实用程序近似（Chipman等人，2010年）。与多项式逻辑模型相比，MNP不假定独立的替代方案，并且可以通过多元高斯分布式潜在实用程序指定替代方案之间的相关结构。我们介绍了两种新算法，以拟合MPBART，并表明我们的提案的理论混合速率相等或优于KD中现有的算法。通过模拟，我们探讨了方法对参考水平的选择，结果频率的不平衡以及实用程序误差项的先前超参数的规格。这项工作是由基于电子健康记录（EHR）从肯尼亚提供医疗保健（AMPATH）的学术模型中的电子健康记录（EHR）来实现后验预测分布来在HIV阳性患者中进行护理的后验预测分配的动机。在应用程序和模拟中，与KD相比，在MCMC收敛速率和后验预测精度方面，我们使用建议的性能更好。

Deep-learning of artificial neural networks (ANNs) is creating highly functional tools that are, unfortunately, as hard to interpret as their natural counterparts. While it is possible to identify functional modules in natural brains using technologies such as fMRI, we do not have at our disposal similarly robust methods for artificial neural networks. Ideally, understanding which parts of an artificial neural network perform what function might help us to address a number of vexing problems in ANN research, such as catastrophic forgetting and overfitting. Furthermore, revealing a network's modularity could improve our trust in them by making these black boxes more transparent. Here we introduce a new information-theoretic concept that proves useful in understanding and analyzing a network's functional modularity: the relay information $I_R$. The relay information measures how much information groups of neurons that participate in a particular function (modules) relay from inputs to outputs. Combined with a greedy search algorithm, relay information can be used to {\em identify} computational modules in neural networks. We also show that the functionality of modules correlates with the amount of relay information they carry.

In recent years multi-label, multi-class video action recognition has gained significant popularity. While reasoning over temporally connected atomic actions is mundane for intelligent species, standard artificial neural networks (ANN) still struggle to classify them. In the real world, atomic actions often temporally connect to form more complex composite actions. The challenge lies in recognising composite action of varying durations while other distinct composite or atomic actions occur in the background. Drawing upon the success of relational networks, we propose methods that learn to reason over the semantic concept of objects and actions. We empirically show how ANNs benefit from pretraining, relational inductive biases and unordered set-based latent representations. In this paper we propose deep set conditioned I3D (SCI3D), a two stream relational network that employs latent representation of state and visual representation for reasoning over events and actions. They learn to reason about temporally connected actions in order to identify all of them in the video. The proposed method achieves an improvement of around 1.49% mAP in atomic action recognition and 17.57% mAP in composite action recognition, over a I3D-NL baseline, on the CATER dataset.

Direct speech-to-speech translation (S2ST), in which all components can be optimized jointly, is advantageous over cascaded approaches to achieve fast inference with a simplified pipeline. We present a novel two-pass direct S2ST architecture, {\textit UnitY}, which first generates textual representations and predicts discrete acoustic units subsequently. We enhance the model performance by subword prediction in the first-pass decoder, advanced two-pass decoder architecture design and search strategy, and better training regularization. To leverage large amounts of unlabeled text data, we pre-train the first-pass text decoder based on the self-supervised denoising auto-encoding task. Experimental evaluations on benchmark datasets at various data scales demonstrate that UnitY outperforms a single-pass speech-to-unit translation model by 2.5-4.2 ASR-BLEU with 2.83x decoding speed-up. We show that the proposed methods boost the performance even when predicting spectrogram in the second pass. However, predicting discrete units achieves 2.51x decoding speed-up compared to that case.

Quantifying motion in 3D is important for studying the behavior of humans and other animals, but manual pose annotations are expensive and time-consuming to obtain. Self-supervised keypoint discovery is a promising strategy for estimating 3D poses without annotations. However, current keypoint discovery approaches commonly process single 2D views and do not operate in the 3D space. We propose a new method to perform self-supervised keypoint discovery in 3D from multi-view videos of behaving agents, without any keypoint or bounding box supervision in 2D or 3D. Our method uses an encoder-decoder architecture with a 3D volumetric heatmap, trained to reconstruct spatiotemporal differences across multiple views, in addition to joint length constraints on a learned 3D skeleton of the subject. In this way, we discover keypoints without requiring manual supervision in videos of humans and rats, demonstrating the potential of 3D keypoint discovery for studying behavior.

In real-world time series recognition applications, it is possible to have data with varying length patterns. However, when using artificial neural networks (ANN), it is standard practice to use fixed-sized mini-batches. To do this, time series data with varying lengths are typically normalized so that all the patterns are the same length. Normally, this is done using zero padding or truncation without much consideration. We propose a novel method of normalizing the lengths of the time series in a dataset by exploiting the dynamic matching ability of Dynamic Time Warping (DTW). In this way, the time series lengths in a dataset can be set to a fixed size while maintaining features typical to the dataset. In the experiments, all 11 datasets with varying length time series from the 2018 UCR Time Series Archive are used. We evaluate the proposed method by comparing it with 18 other length normalization methods on a Convolutional Neural Network (CNN), a Long-Short Term Memory network (LSTM), and a Bidirectional LSTM (BLSTM).

Surgical activity recognition and prediction can help provide important context in many Robot-Assisted Surgery (RAS) applications, for example, surgical progress monitoring and estimation, surgical skill evaluation, and shared control strategies during teleoperation. Transformer models were first developed for Natural Language Processing (NLP) to model word sequences and soon the method gained popularity for general sequence modeling tasks. In this paper, we propose the novel use of a Transformer model for three tasks: gesture recognition, gesture prediction, and trajectory prediction during RAS. We modify the original Transformer architecture to be able to generate the current gesture sequence, future gesture sequence, and future trajectory sequence estimations using only the current kinematic data of the surgical robot end-effectors. We evaluate our proposed models on the JHU-ISI Gesture and Skill Assessment Working Set (JIGSAWS) and use Leave-One-User-Out (LOUO) cross-validation to ensure the generalizability of our results. Our models achieve up to 89.3\% gesture recognition accuracy, 84.6\% gesture prediction accuracy (1 second ahead) and 2.71mm trajectory prediction error (1 second ahead). Our models are comparable to and able to outperform state-of-the-art methods while using only the kinematic data channel. This approach can enable near-real time surgical activity recognition and prediction.

Objective: Thigh muscle group segmentation is important for assessment of muscle anatomy, metabolic disease and aging. Many efforts have been put into quantifying muscle tissues with magnetic resonance (MR) imaging including manual annotation of individual muscles. However, leveraging publicly available annotations in MR images to achieve muscle group segmentation on single slice computed tomography (CT) thigh images is challenging. Method: We propose an unsupervised domain adaptation pipeline with self-training to transfer labels from 3D MR to single CT slice. First, we transform the image appearance from MR to CT with CycleGAN and feed the synthesized CT images to a segmenter simultaneously. Single CT slices are divided into hard and easy cohorts based on the entropy of pseudo labels inferenced by the segmenter. After refining easy cohort pseudo labels based on anatomical assumption, self-training with easy and hard splits is applied to fine tune the segmenter. Results: On 152 withheld single CT thigh images, the proposed pipeline achieved a mean Dice of 0.888(0.041) across all muscle groups including sartorius, hamstrings, quadriceps femoris and gracilis. muscles Conclusion: To our best knowledge, this is the first pipeline to achieve thigh imaging domain adaptation from MR to CT. The proposed pipeline is effective and robust in extracting muscle groups on 2D single slice CT thigh images.The container is available for public use at https://github.com/MASILab/DA_CT_muscle_seg

The binding problem is one of the fundamental challenges that prevent the artificial neural network (ANNs) from a compositional understanding of the world like human perception, because disentangled and distributed representations of generative factors can interfere and lead to ambiguity when complex data with multiple objects are presented. In this paper, we propose a brain-inspired hybrid neural network (HNN) that introduces temporal binding theory originated from neuroscience into ANNs by integrating spike timing dynamics (via spiking neural networks, SNNs) with reconstructive attention (by ANNs). Spike timing provides an additional dimension for grouping, while reconstructive feedback coordinates the spikes into temporal coherent states. Through iterative interaction of ANN and SNN, the model continuously binds multiple objects at alternative synchronous firing times in the SNN coding space. The effectiveness of the model is evaluated on synthetic datasets of binary images. By visualization and analysis, we demonstrate that the binding is explainable, soft, flexible, and hierarchical. Notably, the model is trained on single object datasets without explicit supervision on grouping, but successfully binds multiple objects on test datasets, showing its compositional generalization capability. Further results show its binding ability in dynamic situations.